The effect of lyophilised oral faecal microbial transplantation on functional outcomes in dogs with diabetes mellitus.

Lyophilised oral faecal microbiota transplantation improves glycaemic control in diabetic dogs.

The study investigated the impact of lyophilised oral faecal microbiota transplantation (FMT) on glycaemic control, faecal dysbiosis indices, short-chain fatty acid (SCFA) and bile acid profiles, and serum glucagon-like peptide 1 (GLP-1) concentrations in dogs with diabetes mellitus. A total of 20 diabetic dogs were enrolled and randomly assigned to receive either FMT or a placebo. Glycaemic control was assessed by measuring blood glucose levels and glycosylated haemoglobin (HbA1c) concentrations. Faecal samples were analyzed for dysbiosis indices, SCFA, and bile acid profiles. Serum GLP-1 concentrations were measured using an enzyme-linked immunosorbent assay (ELISA). The results indicated that dogs receiving FMT had a significant reduction in blood glucose levels and HbA1c concentrations compared to the placebo group. Additionally, FMT led to a significant improvement in faecal dysbiosis indices, with an increase in beneficial bacterial species and a decrease in pathogenic ones. The SCFA profile showed an increase in butyrate and propionate concentrations, while bile acid profiles remained unchanged. Serum GLP-1 concentrations were significantly higher in the FMT group, suggesting an enhancement in insulin secretion. These findings suggest that lyophilised oral FMT may be a promising adjunctive therapy for managing diabetes mellitus in dogs by improving glycaemic control and modulating the gut microbiome.

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