Outcome of treatment with a 10-week COP protocol in cats with intermediate or large cell lymphoma: 27 cases (2014-2023).

The COP-10 protocol provides effective treatment for feline intermediate or large cell lymphoma.

This retrospective clinical study evaluated the efficacy of a 10-week maintenance-free COP (COP-10) chemotherapy protocol in 27 cats diagnosed with intermediate or large cell lymphoma between 2014 and 2023. The median age of the cats was 10 years, with 67% in clinical stages I to II, and the most common anatomical location of the lymphoma was alimentary (37%). The overall response rate to the COP-10 protocol was 65%, comprising 38% complete remission and 27% partial remission. For cats achieving complete remission, the median progression-free interval and lymphoma-specific survival time were both 1,139 days. In contrast, cats in partial remission had a median progression-free interval of 53 days and a median lymphoma-specific survival time of 210 days. Clinical stage was significantly associated with treatment response and survival time, indicating that cats in earlier stages of lymphoma had better outcomes. These findings suggest that the COP-10 protocol offers remission rates and durable first remissions comparable to those seen with longer-duration chemotherapy protocols, potentially impacting economic and logistical decisions for owners and improving the quality of life for feline patients. ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/39113405/?utm_source=openai))

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