Analysis of paraoxonase-1 activity and cupric reducing antioxidant capacity in cerebrospinal fluid of dogs with neurological disorders.

CSF PON1 activity may help differentiate inflammatory CNS diseases in dogs.

This study investigated paraoxonase-1 (PON1) activity and total antioxidant capacity (TAC) in cerebrospinal fluid (CSF) of dogs with various neurological disorders. The researchers analyzed CSF samples from dogs with idiopathic epilepsy (IE), intracranial tumors (IT), inflammatory CNS pathologies (INF), and acute/chronic intervertebral disc herniations (AH/CH). PON1 activity and CUPRAC (cupric reducing antioxidant capacity) measurements were performed within three months of sample collection. While CUPRAC values showed no significant differences between groups, PON1 activity was significantly elevated in the inflammatory CNS disease group compared to idiopathic epilepsy, intracranial tumors, and acute intervertebral disc herniation groups. These findings suggest PON1 activity in CSF may serve as a biomarker for distinguishing inflammatory-based CNS pathologies in dogs. The authors conclude that CSF PON1 activity assessment warrants further investigation to establish its clinical utility in canine neurology, potentially providing diagnostic value when standard clinical techniques prove inconclusive.

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