The evaluation of inflammation and oxidative stress following successful non-surgical uterine flushing in Tuj sheep using a Wallace Sure Pro® catheter.

Wallace Sure Pro® catheter enables effective uterine flushing in sheep with manageable inflammation but sustained oxidative stress.

This study evaluated the Wallace Sure Pro® catheter combined with negative pressure for transcervical uterine flushing in 20 Tuj breed sheep. The procedure demonstrated high technical efficacy with a 97.28% fluid recovery rate and successful cervical transit (66.18 seconds average). Blood samples collected at baseline, immediately post-procedure, and at 2, 4, and 6 hours post-procedure revealed transient inflammatory and oxidative stress responses. Serum cortisol and TNF-α levels elevated immediately post-procedure but normalized by 2-4 hours, indicating manageable acute stress response. However, oxidative stress markers showed prolonged elevation: malondialdehyde increased at 2-6 hours post-procedure, while total antioxidant capacity decreased at 4 hours. These findings suggest the procedure is effective and well-tolerated, though the sustained oxidative stress response warrants consideration of post-procedure antioxidant interventions in clinical practice.

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