Evaluation of a point-of-care device for creatinine measurement in nonazotemic pigs presented to a referral hospital.

The Nova StatSensor POC device is not recommended for creatinine screening in nonazotemic pigs due to poor agreement with reference analyzers.

This prospective clinical study evaluated the agreement between a point-of-care (POC) creatinine measurement device (Nova StatSensor; NSS) and a reference laboratory chemistry analyzer (comparison method; CM) in 61 nonazotemic pigs presented to Cornell Nemo Farm Animal Hospital. Two sample collection methods were assessed: heparinized venous blood (NSSven; n=110 measurements) and ear prick whole blood (NSSear; n=71 measurements), with all NSS measurements performed in triplicate. Mean creatinine concentrations differed across methods: CM yielded 1.3 ± 0.52 mg/dL, NSSven produced 1.1 ± 0.43 mg/dL, and NSSear yielded 1.2 ± 0.42 mg/dL. Bland-Altman analysis revealed a negative bias for both NSS methods relative to the CM (NSSven: -0.17 mg/dL; NSSear: -0.21 mg/dL), with wide 95% limits of agreement (NSSven: -0.88 to 0.54 mg/dL; NSSear: -1.04 to 0.62 mg/dL). Equivalence testing failed to demonstrate acceptable equivalence within a ±0.3 mg/dL threshold. Intraclass correlation coefficients and paired t-tests further confirmed statistically significant differences between the POC device and the CM. Given the clinically meaningful discrepancies observed and the failure to meet equivalence criteria, the authors conclude that the Nova StatSensor is not suitable for creatinine screening in nonazotemic pigs. Clinicians should rely on validated laboratory analyzers for renal function assessment in this species, and caution is warranted when extrapolating POC device performance from human or companion animal validations to swine populations.

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