Evaluation of the Antimicrobial Activity of a 3% Chlorhexidine/Ophytrium Mousse and Shampoo in 18 Healthy Dogs.

3-minute shampoo contact time is effective; mousse provides ≥4 days residual antimicrobial activity.

This in vitro study evaluated the antimicrobial efficacy of a 3% chlorhexidine/ophytrium formulation in both shampoo and mousse forms against common canine pathogens. Eighteen healthy dogs were treated with the shampoo at contact times of 3, 5, and 10 minutes, while the mousse was applied once with sampling at days 0, 2, 4, 7, and 14. Both formulations demonstrated inhibitory activity against meticillin-susceptible and -resistant Staphylococcus pseudintermedius, Escherichia coli, ESBL-producing E. coli, Pseudomonas aeruginosa, and Malassezia pachydermatis. The shampoo showed no significant differences in antimicrobial activity across the three contact times, with 3 minutes proving noninferior to 10 minutes. The mousse demonstrated sustained residual activity for at least 4 days against all tested organisms. These findings suggest that shorter contact times with the shampoo may be adequate clinically, potentially improving compliance in pyoderma management, while the mousse provides prolonged antimicrobial coverage.

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