Topical oxygen therapy with hyaluronic acid improves wound healing in small animals.

TOT+HA significantly accelerates wound healing in dogs and cats versus standard dressings.

This prospective, single-blind, randomized controlled trial evaluated topical oxygen therapy (TOT) with and without hyaluronic acid (HA) for treating open wounds in small animals. Forty-six wounds in 34 dogs and 8 cats were assigned to three groups: TOT alone, TOT+HA, and standard care control (honey and bandages). Oxygen was delivered at 5 L/min for 10-minute sessions every 3-5 days until complete healing. Wound assessment used the Bates-Jensen Wound Assessment Tool (BWAT), where lower scores indicate improved healing. At 21 days, TOT+HA-treated wounds showed significantly lower BWAT scores compared to other groups. Statistically significant improvements were noted in epithelialization and area at day 7, and in edges, granulation tissue, and epithelialization at day 21 with TOT+HA treatment. The adjuvant TOT+HA therapy demonstrated superior healing compared to standard dressings, with the treatment proving safe, effective, and practical for clinical application in managing open wounds in dogs and cats.

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