Prevalence, breed predispositions, and culture and sensitivity results of bacterial hepatobiliary infections in dogs in the United Kingdom.

Miniature Schnauzers and Border terriers are predisposed to bacterial hepatobiliary infections with emerging antimicrobial resistance.

This retrospective multicenter study analyzed 126 dogs with bacterial hepatobiliary infections from 71,036 dogs presenting to UK referral hospitals, establishing a prevalence of 0.15%. The research identified significant breed predispositions, with Miniature Schnauzers showing an 8.95-fold increased odds and Border terriers a 3.21-fold increased odds compared to crossbreeds. Bacterial culture revealed E. coli as the most common isolate (44.9%), followed by Enterococcus species (16.7%), with 28.9% of dogs yielding multiple isolates. Antimicrobial susceptibility analysis demonstrated concerning resistance patterns: 44.7% of isolates were multidrug resistant, 29.3% showed fluoroquinolone resistance, and 16.3% were resistant to amoxicillin-clavulanate at first detection. Despite these resistance findings, most isolates remained susceptible to amoxicillin-clavulanate, providing guidance for empirical therapy selection in bacterial hepatobiliary infections.

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