Evaluation of platelet surface-associated immunoglobulin positivity and its association with hematologic findings and vector-borne pathogens in thrombocytopenic dogs.

PSAIG positivity correlates with E. canis infection and Anaplasma co-exposure in thrombocytopenic dogs.

This prospective cohort study evaluated 69 thrombocytopenic dogs to assess associations between platelet surface-associated immunoglobulin (PSAIG) positivity and hematologic parameters, thrombocytopenia severity, and vector-borne pathogen exposure. PSAIG-positive dogs (n=16) demonstrated significantly lower platelet counts and platelet-to-lymphocyte ratios compared to PSAIG-negative dogs (n=53). Logistic regression analysis identified associations between PSAIG positivity and lower platelet counts, reduced automated PLR, Ehrlichia canis PCR positivity, and Anaplasma seropositivity. The strongest association occurred with concurrent E. canis infection and Anaplasma exposure (OR 15.3). These findings suggest immune-mediated platelet destruction mechanisms in infected dogs, with vector-borne pathogens playing a significant role in PSAIG expression and thrombocytopenia severity in this population.

This summary was distilled by AI and may occasionally misinterpret data. Confirm critical details with the primary literature before clinical application.