Long-term outcome and adverse events following calcium electroporation in 4 dogs with solid malignant tumors.

Calcium electroporation shows promise as safe, non-invasive treatment for canine malignant tumors.

This prospective case series evaluated calcium electroporation as a novel treatment for canine solid malignant tumors in 4 dogs with oral melanoma, digital melanomas, and subcutaneous mast cell tumor. Dogs received either one or two treatment sessions with long-term follow-up of 180-870 days. At day 180, 75% of tumors responded to treatment, with three dogs showing no clinical progression at final follow-up (570-870 days). Tumor volume reduction among responders ranged from 85-100%. Adverse events were minimal and transient, including muscle contractions during pulse delivery, mild swelling with erythema lasting 1-3 days, and one self-limiting grade 1 ulcer. Pain scores remained low and owners reported consistently good quality of life. The study demonstrates that calcium electroporation offers potential as a non-invasive, chemotherapy-free, surgery-free local ablative treatment option for canine malignant tumors. However, conclusions are limited by the small sample size of four cases.

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