Partial cystectomy and adjuvant chemotherapy are associated with prolonged survival in dogs and cats with nontrigonal urothelial carcinoma (2010-2014).

Complete margins and adjuvant chemotherapy improve survival in nontrigonal urothelial carcinoma.

This retrospective study evaluated surgical and survival outcomes in 30 dogs and cats (20 dogs, 10 cats) with nontrigonal urothelial carcinoma treated with partial cystectomy between 2010-2024. Overall median survival time was 512 days with a disease-free interval of 255 days. Dogs averaged 498 days survival while cats survived 730 days. Multivariate analysis identified complete surgical margins (HR 0.27) and adjuvant chemotherapy (HR 0.24) as independent positive prognostic factors. Postoperative complications occurred in 53% of cases, with local recurrence in 40% and distant metastasis in 17%. The authors concluded that partial cystectomy as part of multimodal therapy can prolong survival in appropriately selected cases, though the substantial complication rate and high recurrence risk necessitate careful patient selection and realistic client expectations regarding palliative intent.

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