Effect of non-ionic contrast media on invasive pressure measurements during minimally invasive occlusion of patent ductus arteriosus and balloon valvuloplasty for valvular pulmonic stenosis in dogs.

Obtain invasive pressures before contrast administration if using for surgical decisions.

This prospective observational study investigated hemodynamic effects of non-ionic contrast media (iohexol) on invasive pressure measurements in dogs undergoing minimally invasive cardiac procedures. Twenty-six client-owned dogs were included: 14 undergoing patent ductus arteriosus (PDA) occlusion and 12 undergoing balloon valvuloplasty for pulmonic stenosis (PS). Invasive pressures were measured before contrast injection, 60-90 seconds post-injection, and 5 minutes post-injection. Statistically significant pressure changes occurred in both groups, including diastolic and mean aortic pressures in PDA dogs and main pulmonary artery systolic pressure in PS dogs. Although many mean pressure differences were not statistically significant across the entire cohort, 95% tolerance intervals revealed potentially clinically meaningful individual variations. The authors recommend obtaining invasive pressure measurements prior to contrast administration when pressures are used for intraoperative surgical decision-making. Study limitations include small sample size, lack of anesthetic standardization, absence of control group, and evaluation of only one contrast brand.

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