EXPRESS: Feline plasma cell pododermatitis with concurrent glomerular disease: a case series of 25 cats.

PCP-affected young male cats require monitoring for concurrent glomerular disease with SDS-PAGE testing.

This case series of 25 cats with feline plasma cell pododermatitis (PCP) and concurrent glomerular disease (2017-2025) demonstrates an important clinical association previously underrecognized. Affected cats were predominantly young (<5 years) neutered males presenting with marked anemia, hyperglobulinemia, and proteinuria. Renal histopathology revealed immune complex glomerulonephritis in 82% (14/17) of cases examined. Urine SDS-PAGE proved valuable for identifying glomerular dysfunction, demonstrating consistent evidence of glomerular damage across the cohort. Standard renal ultrasound findings were nonspecific, limiting diagnostic utility. Immunosuppressive therapy represented the primary treatment approach for renal disease; however, diagnosis was frequently delayed due to diagnostic challenges in identifying glomerular disease as the underlying etiology. The prognosis was poor, with median survival of approximately one month following renal disease onset. These findings suggest that cats presenting with PCP warrant close monitoring for glomerular disease development, particularly in young males, and that urine SDS-PAGE should be considered a valuable diagnostic tool in this patient population.

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