Elevation of the slope of inverse creatinine to define progressive chronic kidney disease in cats and associated risk factors.

Reciprocal creatinine slope differentiates progressive from stable feline CKD; FGF-23 predicts early progression.

This retrospective study analyzed 321 euthyroid cats with azotaemic chronic kidney disease (CKD) to establish objective criteria for distinguishing stable from progressive disease. Researchers used a reciprocal creatinine plot (1/creatinine vs time) to identify a slope cutoff of -9.5×10⁻³ L/μmol/month that differentiated 231 stable CKD cats from 90 progressive cats. Stable CKD was defined as <25% plasma creatinine increase over >365 days. Independent risk factors for progression within 84 days of diagnosis included elevated baseline fibroblast growth factor-23 (FGF-23), lower albumin concentrations, advanced age, and steeper slopes of creatinine, phosphate, and body weight decline. Progressive CKD cats demonstrated significantly shorter median survival (287 vs 894 days). This methodology provides veterinarians with objective tools to predict disease progression early, enabling timely therapeutic intervention in high-risk patients and more accurate prognostic counseling.

This summary was distilled by AI and may occasionally misinterpret data. Confirm critical details with the primary literature before clinical application.