A single pneumatic tourniquet is superior to wide rubber tourniquets for saphenous intravenous regional limb perfusion with amikacin in standing, sedated horses.

Single mid-gaskin pneumatic tourniquet preferred for saphenous IVRLP in standing sedated horses.

This randomized, crossover study evaluated four saphenous intravenous regional limb perfusion (IVRLP) protocols in eight healthy horses using different tourniquet configurations (single vs. dual) and types (pneumatic vs. wide rubber) with 2g amikacin. Synovial fluid and serum amikacin concentrations were measured from the tarsocrural and metatarsophalangeal joints at 15 and 30 minutes post-perfusion. Results demonstrated that single pneumatic tourniquets achieved synovial fluid amikacin concentrations equivalent to or superior compared to dual-tourniquet protocols. Pneumatic tourniquets produced significantly lower serum amikacin concentrations than wide rubber tourniquets, indicating reduced systemic leakage. Mean synovial concentrations were higher with dual pneumatic versus dual wide rubber tourniquets. The findings suggest that simplifying the tourniquet approach from dual to single tourniquet placement does not compromise therapeutic drug delivery to target joints while reducing procedural complexity in standing, sedated horses.

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