Evaluation of the Effects of Intravenous Lipid Emulsion Administration on Coagulation Parameters in Healthy Dogs.

ILE at antidotal dose is safe in healthy dogs with no clinically relevant coagulation effects.

This prospective crossover study evaluated coagulation effects of 20% intravenous lipid emulsion (ILE) in 12 healthy Beagles using standard antidotal dosing protocol. Dogs received either ILE (2 mL/kg bolus followed by 0.25 mL/kg/min infusion) or lactated Ringer's solution with crossover after one week washout. Coagulation parameters including viscoelastic monitoring, prothrombin time (PT), activated partial thromboplastin time (aPTT), and platelet counts were measured before and after treatment. ILE administration resulted in statistically significant increases in clot formation time and decreases in alpha angle and amplitudes at 10 and 20 minutes compared to control. However, most values remained within reference intervals, suggesting limited clinical significance. PT increased after LRS but not ILE. No significant changes in aPTT or platelet counts occurred in either group. The authors concluded ILE was well-tolerated at antidotal doses without clinically relevant coagulation effects in healthy dogs, though viscoelastic findings suggested mild relative hypocoagulability.

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