Urinary protein electrophoresis pattern is associated with prognosis in dogs with proteinuric chronic kidney disease.

Urine protein electrophoresis patterns independently predict CKD progression and survival in dogs.

This retrospective study evaluated 100 dogs with proteinuric chronic kidney disease to determine whether urine protein electrophoresis (UPE) patterns predict disease progression and survival. Using sodium dodecyl sulfate-agarose gel electrophoresis (SDS-AGE), dogs were classified into three groups: glomerular (n=47), mixed (n=40), and tubular (n=13) profiles. Dogs with tubular patterns demonstrated significantly accelerated disease progression, reaching a 25% increase in serum creatinine within a median of 2 months compared to 24 months in glomerular cases. The creatinine slope over the first year was substantially steeper in tubular cases (56 vs. 7 µmol/L/month). Most notably, tubular patterns were independently associated with markedly reduced CKD-related survival (median 1 month vs. 55 months for glomerular cases). Mixed patterns also predicted worse outcomes than glomerular patterns (median 12 vs. 55 months). These findings suggest that SDS-AGE profiling provides prognostic information independent of other biochemical variables and should be incorporated into the initial evaluation of proteinuric CKD in dogs.

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