EXPRESS: Oral lotilaner in 21 cats with naturally acquired harvest mite infestation: a case series.

Oral lotilaner achieves complete clinical resolution in harvest mite-infested cats within 14 days.

This case series evaluated oral lotilaner treatment in 21 client-owned cats with naturally acquired harvest mite infestation. Cats were diagnosed through visual identification of characteristic orange larvae on the skin at baseline. Twelve cats underwent microscopic parasitological evaluation with semi-quantitative mite scoring and viability assessment, while nine were assessed clinically by visual inspection. At baseline, 76.2% of cats presented with inflammatory skin lesions and pruritus, predominantly affecting the head and neck region (85.7%), while 23.8% were clinically healthy despite visible larvae. In the microscopically evaluated subgroup, live mites were detected in all cats at baseline, in 2/12 cats at Day 7, and in none at Day 14. Complete clinical resolution was observed in all cats by Day 7 or Day 14. No adverse events were reported. The consistent temporal association between single-dose oral lotilaner treatment and clinical/parasitological improvement supports its practical use in affected cats, though the absence of an untreated control group limits stronger efficacy conclusions.

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