Serum Endothelial Glycocalyx Biomarkers in Dogs Anesthetized With Isoflurane or Sevoflurane: A Randomized, Prospective Study.

Sevoflurane and isoflurane produce similar endothelial glycocalyx effects in anesthetized dogs.

This randomized controlled trial compared endothelial glycocalyx biomarkers in 28 client-owned dogs undergoing general anesthesia with either sevoflurane or isoflurane. Serum syndecan-1 (SDC1) and hyaluronan (HA) concentrations were measured before and after anesthesia using validated ELISA kits. Results demonstrated no significant differences in postanesthetic SDC1 or HA concentrations between the sevoflurane and isoflurane groups. However, HA levels showed a statistically significant decrease after anesthesia in both groups. The study evaluated secondary outcomes including anesthesia duration, intraoperative medications, perioperative complications, and crystalloid administration. The findings suggest that neither volatile anesthetic agent produced differential effects on endothelial glycocalyx integrity as measured by these biomarkers, though both anesthetics were associated with decreased HA levels postoperatively, which may indicate some degree of glycocalyx degradation independent of anesthetic choice.

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