Floppy rabbit syndrome: A retrospective study of clinicopathological data and outcomes.

FRS is self-limiting with excellent prognosis; avoid euthanasia in affected rabbits.

Floppy rabbit syndrome (FRS) is an idiopathic neurological condition characterized by peracute onset of tetraparesis with generalized weakness and decreased muscle tone and spinal reflexes. This retrospective study analyzed nine pet rabbits presenting with non-ambulatory tetraparesis consistent with FRS. Clinical examination revealed otherwise unremarkable presentations, but all animals demonstrated significantly elevated serum creatine kinase (CK) concentrations, which may aid in differential diagnosis. Eight of nine rabbits achieved complete recovery within a short timeframe, indicating FRS is typically self-limiting. The study was limited by small patient numbers and absence of muscle biopsy and electromyography data. The consistent clinical presentation and neurological examination findings enable clear diagnosis of FRS. Since the condition is self-limiting and does not require specific treatment, euthanasia should be avoided in affected rabbits. Serum CK determination serves as a useful diagnostic aid to differentiate FRS from other neurological diseases in rabbits.

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