Urine protein electrophoresis analysis in dogs with systemic inflammatory response syndrome.

Urine LMW/HMW ratio predicts mortality and early renal damage in canine SIRS.

This retrospective study evaluated urine protein electrophoresis patterns in proteinuric dogs with and without systemic inflammatory response syndrome (SIRS) using SDS-PAGE analysis. The research included 10 dogs with SIRS and 21 without SIRS. The key finding was that the low molecular weight to high molecular weight protein ratio (LMW/HMW) was significantly elevated in SIRS dogs, as was the proportion of 20-30 kDa proteins. The LMW/HMW ratio demonstrated significant correlations with inflammatory markers (C-reactive protein, globulin, WBC, band neutrophils) and renal markers (BUN, symmetric dimethylarginine). Most notably, the LMW/HMW ratio showed strong predictive value for mortality within 2, 4, and 8 weeks, with AUC values of 0.844, 0.867, and 0.944 respectively. These findings suggest that elevated low molecular weight proteinuria detected via urine electrophoresis represents early renal damage in SIRS patients and serves as both a diagnostic and prognostic indicator, potentially more sensitive than conventional serum biomarkers.

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