Detection of neural autoantibodies in dogs with non-infectious inflammatory central nervous system disorders.

Neural autoantibodies detected via IIF assays may serve as biomarkers in canine non-infectious inflammatory CNS disorders.

This prospective study investigated neural autoantibodies in 23 dogs with non-infectious inflammatory central nervous system (CNS) disorders using indirect immunofluorescence assays adapted from human neurology. Researchers analyzed serum and cerebrospinal fluid samples for specific autoantibodies. Results revealed astrocytic autoantibodies against glial fibrillary acidic protein in 2 dogs, neuronal autoantibodies against N-methyl-D-aspartate receptors in 2 dogs, and autoantibodies against tripartite motif-containing protein 46 in 1 dog. Additionally, myelin-targeting autoantibodies were suspected in 6 dogs, and myelin-oligodendrocyte glycoprotein autoantibodies in 4 dogs. One dog had uncharacterized neuronal surface autoantibodies. The study demonstrated that tissue-based immunofluorescence assays followed by cell-based confirmation proved effective for detecting neural autoantibodies in canine inflammatory CNS diseases. These findings suggest potential biomarkers for diagnosis of non-infectious inflammatory CNS disorders in dogs, though further validation and larger studies are needed for clinical application.

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