Laparoscopic-induced pneumoperitoneum does not impair oxygenation in large-breed dogs but worsens hypercapnia, which is improved by low positive end-expiratory pressure ventilation.

Use PEEP-3 PCV during large-breed dog laparoscopy to improve ventilation without oxygenation impairment.

This study evaluated the effects of laparoscopic-induced pneumoperitoneum in reverse Trendelenburg position on ventilation and oxygenation in sevoflurane-anesthetized large-breed dogs. Researchers compared spontaneous ventilation (SV) with pressure-controlled ventilation (PCV) using different PEEP levels (3 or 5 cm H2O). During SV, pneumoperitoneum significantly worsened hypercapnia and acidemia without affecting oxygenation. When PCV was initiated with PEEP-3, respiratory variables improved substantially after titrating peak inspiratory pressure to 16 cm H2O. Conversely, PEEP-5 resulted in persistent lower pH and increased dead space-to-tidal volume ratio, potentially limited by pressure constraints. Cardiovascular parameters and oxygenation remained unaffected across both groups. The findings demonstrate that while laparoscopic procedures with pneumoperitoneum in reverse Trendelenburg position impairs ventilation in large-breed dogs, low PEEP-3 PCV effectively ameliorates hypoventilation without compromising oxygenation, making it the preferred ventilation strategy during these procedures.

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