EXPRESS: Evaluation of analytical characteristics of the Vcheck C10 point-of-care chemistry analyzer for feline sera.

Vcheck C10 reliable for most feline chemistry parameters; use analyzer-specific reference intervals.

This analytical validation study evaluated the Vcheck C10 point-of-care dry chemistry analyzer for feline serum testing against the AU480 reference wet chemistry system. Using 57 feline serum samples, researchers assessed 16 biochemical analytes for precision, accuracy, and agreement. Within-run and between-run precision testing showed acceptable results for most analytes, though total bilirubin (TBIL) exhibited increased variability at lower concentrations. Passing-Bablok regression demonstrated strong linear correlations (r = 0.82-0.99) for most analytes, with Bland-Altman analysis showing 94.4-98.0% of results within acceptable agreement limits. However, total observed error (TEobs) exceeded allowable limits (TEₐ) for five analytes: BUN, calcium (CA), creatinine (CREA), TBIL, and total protein (TP). The authors concluded that while the Vcheck C10 offers reliable point-of-care testing for most feline biochemical parameters in primary practice settings, certain analytes require cautious interpretation and should utilize analyzer-specific reference intervals rather than values derived from reference methods.

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