Severe Toxicosis Secondary to Accidental Oclacitinib Ingestion in Three Cats.

Accidental oclacitinib overdose causes severe acute kidney injury in cats; supportive care essential.

This case series describes three cats that ingested large overdoses of oclacitinib (>100 mg/kg), a Janus kinase inhibitor commonly used for pruritus management in dogs. All three cats developed severe acute kidney injury with associated systemic illness. Two cats died or were euthanized despite treatment, while one cat recovered fully following intensive supportive care. Necropsies on the two deceased cats failed to identify a definitive toxicological mechanism. The authors emphasize that this represents the first documented case series of accidental oclacitinib toxicosis in felines. The clinical presentation and poor prognosis in two of three cases highlight the severity of overdose exposure in this species. While oclacitinib's mechanism of renal toxicity remains unclear, the findings suggest cats may be particularly susceptible to complications from accidental ingestion. The authors stress the importance of clinical awareness regarding exposure risk minimization and recommend prompt, aggressive supportive care in overdose situations, including fluid therapy and monitoring of renal function.

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