Evaluation of maropitant's analgesic and tissue relaxation effects during ovariohysterectomy in bitches.

Maropitant provides superior perioperative analgesia with easier surgical manipulation versus methadone.

This prospective, randomized, blinded clinical trial evaluated maropitant as an analgesic agent in female dogs undergoing ovariohysterectomy, comparing it against methadone co-administered with dexmedetomidine. Seventy-two healthy bitches were enrolled across two treatment groups (methadone n=34, maropitant n=38). The study assessed intraoperative cardiorespiratory parameters, anesthetic requirements, postoperative pain using the CMPS-SF scale, and surgical ease of ovarian exteriorization. Results demonstrated that maropitant-treated dogs exhibited elevated heart and respiratory rates during ovarian traction, facilitated ovary exteriorization, achieved lower postoperative pain scores at 0, 1, and 2 hours post-operatively, and required reduced rescue analgesia. These findings suggest maropitant provides effective perioperative analgesia while potentially modulating visceral smooth muscle tone, thereby enhancing surgical conditions and improving postoperative patient comfort during this common elective procedure in small animal surgery.

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