Hemodynamic responses to intravenous maropitant in anesthetized dogs depend on premedication protocol.

Maropitant causes significant hypotension in acepromazine-premedicated anesthetized dogs; dexmedetomidine premedication preferred.

This prospective randomized clinical study evaluated hemodynamic responses to intravenous maropitant in 26 anesthetized Spanish Greyhounds premedicated with either dexmedetomidine or acepromazine, both combined with methadone. Anesthesia was induced with propofol and midazolam, maintained with sevoflurane. After achieving stable anesthesia, dogs received either maropitant (1mg/kg IV) or saline. Invasive arterial blood pressure and heart rate were monitored for 20 minutes. Results demonstrated that dexmedetomidine-premedicated dogs showed only transient diastolic pressure decreases with maropitant, while acepromazine-premedicated dogs experienced more pronounced hemodynamic effects including clinically relevant hypotension (MAP 51±7 mmHg). Both groups showed transient heart rate increases. The study concludes that maropitant is hemodynamically well-tolerated in dexmedetomidine-premedicated anesthetized dogs but produces concerning hypotensive effects when acepromazine is used for premedication, warranting consideration of alternative administration routes in perioperative settings.

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