Dietary-responsive disseminated eosinophilia in a border terrier.

Dietary modification should be considered in eosinophilia cases when other causes excluded.

This case report documents disseminated eosinophilia with multi-organ infiltration in a 15-month-old Border terrier presenting with a 6-month history of recurrent abdominal pain, trembling, vomiting, and soft feces. Diagnostic imaging revealed abdominal lymphadenomegaly, and cytological evaluation demonstrated eosinophilic and neutrophilic pyogranulomatous lymphadenitis. Histopathological examination of jejunal and iliac lymph nodes, liver, and jejunal tissue obtained during exploratory celiotomy confirmed marked eosinophilic infiltration without identifiable underlying etiology. Notably, this case represents an unusual presentation of disseminated eosinophilia in a canine patient. Unlike previously reported cases requiring combined immunosuppressive therapy with prednisolone and hydroxyurea, this patient achieved complete clinical and hematologic remission through dietary modification alone using a gluten-free hydrolyzed diet. This successful outcome highlights the importance of considering dietary factors as a potential etiology in dogs with acute gastrointestinal signs and marked circulating and tissue eosinophilia, particularly when comprehensive diagnostic workup fails to identify conventional causes.

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