The presence of a hypercoagulable state in cats with cardiomyopathies with or without thromboembolic disease: a scoping review.

Von Willebrand Factor and platelet activation consistently elevated in feline cardiomyopathy; further research needed.

This scoping review systematically evaluated literature on thromboembolic disease in cats with cardiomyopathy, examining coagulation pathways and abnormalities. The authors searched PubMed and Scopus through December 2024, identifying 244 studies with 17 ultimately included (15 observational, 2 RCTs). Most studies compared cats with various cardiomyopathy types (hypertrophic, dilated, restrictive) to healthy controls. The most consistent finding across studies was increased von Willebrand Factor and platelet activation. However, remaining results were mixed, attributed to small sample sizes, variable cardiomyopathy severity distribution, inconsistent subgrouping, and potential confounding factors. The review demonstrates significant knowledge gaps in understanding the pathophysiology of thromboembolic complications in feline cardiomyopathy, indicating substantial opportunity for future research and discovery to improve clinical management and outcomes.

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