Plasma ADAMTS13 activity in healthy dogs and dogs with chronic enteropathy.

ADAMTS13 activity reduction is uncommon in canine chronic enteropathy but correlates with disease activity.

This study investigated plasma ADAMTS13 activity in dogs with chronic enteropathy (CE) compared to healthy controls. ADAMTS13 is a von Willebrand factor-cleaving enzyme associated with prothrombotic states in humans and reduced in inflammatory bowel disease. Researchers measured ADAMTS13 activity, von Willebrand factor antigen (vWF:Ag), and von Willebrand factor collagen binding activity (vWF:CBA) in 19 dogs with CE and 40 healthy dogs. Using ELISA methodology and non-parametric statistical analysis, results showed ADAMTS13 activity and vWF:Ag were not significantly different between groups. However, vWF:CBA was lower in CE dogs. Notably, 33% of CE dogs with hypoalbuminemia had reduced ADAMTS13 activity below reference intervals. ADAMTS13 activity negatively correlated with vWF:CBA, vWF:Ag, and disease activity scores in CE dogs. The authors concluded that reduced ADAMTS13 activity is uncommon in CE but correlates with von Willebrand factor parameters and disease severity, particularly in hypoalbuminemic patients.

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