Porcine circovirus 2 vaccination timing was not associated with piglets' serological response.

Timing of PCV2 vaccination relative to weaning does not significantly affect piglets' serological immune response.

This prospective controlled study investigated whether the timing of intradermal porcine circovirus 2 (PCV2) vaccination relative to weaning affects piglets' serological responses. The study comprised two substudies involving 84 piglets each. In substudy A, piglets were vaccinated at 3.5 weeks of age; half were weaned the following day and half one week later. In substudy B, piglets were vaccinated at 4.5 weeks; half were weaned one week prior to vaccination and half the day after. Blood samples were collected at the time of vaccination and four weeks post-vaccination. Serological responses were quantified using an AlphaLISA immunological assay, and group comparisons were performed using Welch's two-sample t-tests. No statistically significant differences in antibody titres were detected between weaning groups at any sampling time point, regardless of whether weaning preceded or followed vaccination. The authors note that this study was limited to humoral (serological) immune assessment; cellular immune responses were not evaluated. These findings suggest that the physiological and psychological stressors associated with weaning do not meaningfully impair piglets' antibody responses to intradermal PCV2 vaccination, providing practitioners with flexibility in scheduling vaccination relative to weaning without concern for compromised serological immunity.

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