Extranodal Lymphoma With Adnexal and Suspected Intracranial Involvement in a Dog.

Adnexal lymphoma diagnosis should prompt reevaluation of concurrent intracranial masses for systemic disease.

This case report describes an 11-year-old female mixed breed dog presenting with a rapidly growing right upper eyelid and medial canthal mass measuring 2.2 cm that compressed the anterior chamber. Notably, the patient had recently undergone radiation therapy for a suspected brain glioma in the piriform lobe approximately one month prior. Histopathological examination of the adnexal mass revealed large B-cell lymphoma. Repeat brain MRI showed resolution of the previously identified intracranial lesion, suggesting the initial brain mass may have been lymphoma rather than glioma. The patient subsequently developed an additional left lower eyelid mass. Treatment with modified CHOP-15 chemotherapy was initiated, resulting in significant regression of eyelid masses within three weeks. However, new cutaneous masses emerged three months post-diagnosis, leading to declining quality of life and euthanasia without necropsy. This case highlights the importance of considering extranodal lymphoma in the differential diagnosis of eyelid masses and demonstrates how adnexal lymphoma diagnosis can prompt reassessment of previously diagnosed intracranial disease, potentially altering treatment strategies from local radiation to systemic chemotherapy.

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