Calcium Corneal Deposits Following Corneal Ulceration in Cats: A Series of Eight Cases.

Calcium corneal deposits in cats following ulceration warrant investigation for systemic calcium metabolism disorders.

This case series describes eight cats presenting with corneal calcium deposits following corneal ulceration management between 2013 and 2022. All cats developed characteristic axial anterior stromal opaque plaques of acute onset after previous corneal ulceration. Seven of eight cats had concurrent comorbidities, including chronic kidney disease (4 cats), ureteral obstruction from calcium oxalate lithiasis (2 cats), polytrauma (2 cats), and suspected spindle cell tumor (1 cat). One cat demonstrated ionized hypercalcemia prior to deposit development. All cases had received topical treatments, most commonly sodium hyaluronate and neomycin-polymyxin B, with six cats receiving methadone. Bacterial and fungal cultures were negative. Histopathological examination confirmed calcium salt deposition in two cases. Superficial keratectomy was successful in two cats with no recurrence during follow-up. This series establishes an association between corneal calcium deposits, prior ulceration, systemic metabolic disorders, and topical medication use in cats, suggesting multifactorial etiology requiring investigation of underlying calcium metabolism abnormalities.

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