Canine Herpesvirus-1 Ocular Infection in Japan: A Case Report.

CHV-1 causes dendritic ulcers, hypoesthesia, and tear deficiency; idoxuridine therapy effective.

This case report documents the first confirmed ocular infection caused by canine herpesvirus-1 (CHV-1) in an adult dog in Japan. A 5-year-old castrated male French Bulldog presented with dendritic corneal ulcers, quantitative tear deficiency, and corneal hypoesthesia in the left eye. Diagnosis was established through characteristic clinical presentation and confirmed via PCR analysis of conjunctival swabs. Treatment with 0.1% idoxuridine ophthalmic solution was initiated on day 8 post-presentation. Serial ophthalmic examinations at days 14, 37, and 58 demonstrated progressive resolution of corneal ulcers with concurrent improvement in corneal sensitivity and tear production. Quantitative PCR analysis revealed significant reduction in viral shedding following antiviral therapy. No recurrence of ocular lesions was observed at final follow-up. This case expands the recognized clinical manifestations of CHV-1 ocular infection beyond typical dendritic ulcers to include associated corneal hypoesthesia and tear film abnormalities, highlighting the importance of considering herpesviral infection in dogs presenting with these combined ocular signs.

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