Effects of Omidenepag Isopropyl Versus Latanoprost Eye Drops on Intraocular Pressure, Pupil Diameter, and Anterior Chamber Parameters in Normal Feline Eyes: A Pilot Study.

OMDI reduces IOP in cats without miosis; latanoprost causes significant pupil constriction.

This pilot study compared omidenepag isopropyl (OMDI), a selective prostaglandin E2 receptor agonist, with latanoprost in 22 cats (44 eyes) to evaluate effects on intraocular pressure (IOP), pupil diameter (PD), and anterior chamber parameters. IOP and PD were measured at baseline, 2, and 4 hours post-administration, while ultrasound biomicroscopy assessed structural parameters including iridocorneal angle, ciliary cleft area and width, angle-opening distance, and ciliary muscle thickness. OMDI significantly reduced IOP without causing miosis (pupil constriction), whereas latanoprost did not significantly lower IOP but caused greater PD reduction. OMDI uniquely increased mid-width of ciliary cleft and ciliary cleft area compared to latanoprost, suggesting enhanced conventional outflow pathway activity. Both medications increased iridocorneal angle and ciliary muscle thickness relative to controls, indicating potential effects on uveoscleral outflow. These findings suggest OMDI may offer superior IOP reduction in cats while avoiding undesirable pupillary effects associated with latanoprost, potentially through distinct mechanisms affecting aqueous humor drainage pathways.

This summary was distilled by AI and may occasionally misinterpret data. Confirm critical details with the primary literature before clinical application.