Measurement of the Retention Time of Two Different Carbomer-Based Ophthalmic Gels With and Without Hyaluronic Acid in Anesthetized Dogs Using Ultrahigh-Resolution Optical Coherence Tomography.

Sodium hyaluronate addition significantly extends ophthalmic gel retention time in anesthetized dogs.

This randomized controlled study evaluated corneal surface retention time of two carbomer-based ophthalmic gels in 20 anesthetized dogs using spectral-domain optical coherence tomography. Dogs received Ocry-gel (carbomer alone) in one eye and Eye Lube Pro (carbomer with sodium hyaluronate) in the contralateral eye. Central Tear Film Thickness was measured at baseline and 10 timepoints over 60 minutes. Eye Lube Pro demonstrated significantly superior retention, with measurable tear film thickness in 14/20 dogs at 60 minutes compared to only 2/20 for Ocry-gel (p<0.001). Statistical analysis using two-way repeated-measures ANOVA found no significant differences based on sex, age, or brachycephalic phenotype. The addition of sodium hyaluronate to carbomer formulation substantially prolonged pre-corneal retention time during general anesthesia, suggesting clinical recommendations should account for anesthesia duration when selecting protective gels and determining administration frequency.

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