Comparision Between the Use of Topical Antibiotic and Septostil in Spontaneous Chronic Corneal Epithelial Defects in Dogs.

Septostil antiseptic drops equivalent to cefazolin for post-debridement SCCED healing in dogs.

This prospective, randomized, blinded study evaluated the efficacy of topical antiseptic (Septostil) versus topical antibiotic (cefazolin) following diamond burr debridement (DBD) in 99 dogs with spontaneous chronic corneal epithelial defects (SCCEDs), encompassing 104 eyes. Dogs were randomized to receive either Septostil or cefazolin four times daily, with follow-up assessments at 1, 2, and 4 weeks post-debridement. Success rates were comparable between groups: 94.4% for Septostil and 92% for cefazolin (p=0.708), with median healing times of 14 days for both groups (p=0.873). Notably, female dogs demonstrated faster epithelial healing compared to males, while skull conformation and prior antibiotic or anti-inflammatory therapy did not significantly influence healing outcomes. The findings suggest that topical antiseptic eye drops represent a viable alternative to antibiotics for prophylactic treatment following SCCED management in dogs. However, the authors acknowledge these results are preliminary, emphasizing the need for larger, definitive studies before drawing firm clinical conclusions regarding treatment protocol standardization.

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