Immediate Effect of Three Artificial Tear Formulations on Tear Film Osmolality in Brachycephalic Dogs.

0.4% sodium hyaluronate artificial tears most effectively reduce tear osmolality in brachycephalic dogs.

This experimental study evaluated the immediate effects of three sodium hyaluronate-based artificial tear formulations on tear film osmolality (TFO) in 40 healthy brachycephalic dogs. Dogs were randomly assigned to four groups: three treatment groups receiving different formulations of artificial tears and one control group receiving sterile water. TFO was measured using an I-PEN VET osmometry system at baseline and 10 minutes post-instillation. Results showed significant reductions in TFO for all treatment groups compared to controls. The 0.4% sodium hyaluronate formulation produced the most substantial decrease of 53.4 mOsm/L (17.3%), followed by the 1.6 mg formulation with a 31.8 mOsm/L reduction (9.9%), and the 0.9 mg formulation with a 17.6 mOsm/L decrease (5.8%). The control group showed minimal change of 3.4 mOsm/L (1.1%). Statistical analysis confirmed significant differences between treatment groups and controls, with Group 1 showing significant superiority over the control group (p=0.006). These findings suggest sodium hyaluronate-containing artificial tears provide meaningful immediate osmolality normalization in brachycephalic dogs.

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