Novel Non-Invasive Treatment for Canine Corneal Ulcers: Application of New Extracellular Matrix-Based Sticky Sealants.

Gelatinized Cod-ECM accelerates healing and improves corneal clarity in canine stromal ulcers.

This randomized controlled study evaluated gelatinized cornea-derived decellularized extracellular matrix (Cod-ECM), a novel adhesive tissue sealant, for treating canine stromal corneal ulcers. Sixty eyes from 56 dogs with ulcers involving less than 50% corneal thickness were enrolled: 30 received gelatinized Cod-ECM with standard medical therapy, while 30 received conventional therapy alone. Both groups achieved complete re-epithelialization. The gelatinized Cod-ECM group demonstrated significantly improved corneal clarity (p < 0.01) and faster epithelialization (3.9 ± 0.7 days versus 5.3 ± 1.0 days, p < 0.01). No significant difference in corneal neovascularization was observed between groups (p = 0.3). The authors conclude that gelatinized Cod-ECM represents a simple, non-invasive, cost-effective treatment option that provides superior corneal transparency and accelerated healing compared to conventional therapy, making it a promising clinical approach despite its lack of effect on vascularization.

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