Systematic evaluation and meta-analysis of prevalence and trends for antibiotic resistance in Canine Pseudomonas infections.

Perform susceptibility testing before fluoroquinolone use for canine Pseudomonas infections.

This systematic review and meta-analysis examined antibiotic resistance patterns in Pseudomonas spp. isolates from 9,911 canine infections across 73 studies. Approximately 48% of isolates were from otitis externa, with the remainder from skin and systemic infections. Fluoroquinolones demonstrated the highest resistance rates (27%), with pradofloxacin (56%) and enrofloxacin (38%) showing particularly concerning resistance proportions. In contrast, aminoglycosides (15%) and carbapenems (8%) demonstrated lower resistance rates. The findings suggest that routine empirical use of fluoroquinolones, particularly enrofloxacin, is creating significant selection pressure for resistance in canine Pseudomonas infections. Aminoglycosides and broad-spectrum beta-lactams are underutilized alternatives. The authors recommend antimicrobial susceptibility testing to guide fluoroquinolone selection for canine Pseudomonas infections, rather than empirical treatment approaches.

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