Long-Term Effects of Various Therapies for Pigmentary Keratitis in Pugs.

MCP combined with topical therapy superior to topical therapy alone for PK management.

This retrospective study evaluated long-term treatment outcomes for pigmentary keratitis (PK) in 76 Pugs across four treatment groups over a minimum 1.5-year follow-up period. Group 1 received topical therapy (TT) alone, Group 2 underwent simplified medial canthoplasty (MCP) with TT, Group 3 received MCP with bilateral corneal cryotherapy (CC) and TT, and Group 4 received MCP with TT and randomized unilateral CC. All treatment groups demonstrated improvements in tear film parameters including Schirmer tear test-1 values, fluorescein staining, and ocular discharge. However, outcomes varied significantly among groups. Groups 1 and 2 achieved PK regression in approximately 25% of cases, with only two dogs in Group 2 achieving complete resolution. Group 3 showed decreased or stable corneal pigmentation in most cases, while Group 4 demonstrated consistent regression of PK in eyes receiving CC treatment. The findings indicate that simplified MCP combined with topical therapy provides superior long-term control compared to topical therapy alone, with adjunctive corneal cryotherapy offering additional benefit in cases with advanced pigmentation, though partial recurrence may occur.

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