Short-Term Daily Oral Administration of Cannabidiol Does Not Impact Rebound Tonometry Intraocular Pressure or Schirmer Tear Test Values in Healthy Adult Horses.

Oral CBD at 3 mg/kg does not significantly affect equine IOP or tear production.

This masked, randomized, cross-over study evaluated the effects of oral cannabidiol (CBD) on intraocular pressure (IOP) and tear production in six healthy adult horses. Horses received either 3 mg/kg CBD in sesame oil or placebo once daily for three days, with measurements taken at baseline and at 4, 12, and 24 hours post-treatment. IOP was measured using rebound tonometry in triplicate without sedation or eyelid akinesia, while Schirmer tear test I was performed at baseline and 24 hours after the final treatment. Results demonstrated no clinically relevant differences in IOP measurements between CBD and placebo treatments. Similarly, no significant differences in tear production were observed between groups. Notably, IOPs were significantly higher during the second treatment period regardless of treatment assignment (p = 0.009), likely reflecting period effects or environmental variation. This study provides evidence that short-term oral CBD administration does not affect these ocular parameters in healthy equine patients, contributing to the limited pharmacological data on cannabinoid effects in veterinary ophthalmology.

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