Ocular Effects of Topical 1% Cyclopentolate in New Zealand White Rabbits: A Controlled Evaluation of Intraocular Pressure, Pupil Size, and Tear Production.

Topical 1% cyclopentolate is safe for rabbit ophthalmologic examination with transient, reversible effects.

This controlled study evaluated the ocular safety and efficacy of topical 1% cyclopentolate in five healthy male New Zealand White rabbits. Each animal received cyclopentolate in the right eye and placebo in the left, with measurements of intraocular pressure (IOP), horizontal pupil diameter (HPD), and tear production via Schirmer tear test (STT1) recorded at baseline and multiple timepoints over 72 hours. Results demonstrated transient IOP elevation at 0.5 hours (2.80 ± 2.49 mmHg, p = 0.008), followed by temporary decreases at 2 and 4 hours, with normalization thereafter. Significant mydriasis occurred within 0.5 hours and peaked at 1 hour before returning to baseline by 8 hours. Importantly, tear production remained unchanged throughout the study period. These findings support the safety profile of topical cyclopentolate for diagnostic purposes in rabbits, with transient and reversible effects on pupil diameter and IOP without compromise to tear film integrity.

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